Genetics of Lupus Nephritis: Clinical Implications
نویسندگان
چکیده
منابع مشابه
Genetics of human lupus nephritis.
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease in which glomerulonephritis represents one of the most severe clinical presentations. Numerous linkage and association studies, as well as the analysis of murine models, have provided ample evidence for a genetic basis for SLE. Genetic susceptibility to SLE results from the combined actions of multiple alleles, each ...
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Introduction: Lupus nephritis is a systemic disease which affects different organs. The present study was designed to review lupus nephritis, in children its outcome and the related factors. Methods: We reviewed 48 children with lupus nephritis. Clinical and epidemiological features were studied. The patients’ outcomes and related factors were analyzed. Patient and renal survival rate were ca...
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The significance of necrosis (karyorrhexis), among the most characteristic findings in lupus nephritis, was evaluated by studying the correlation between the existence of necrosis in renal biopsy specimens and laboratory findings. The subjects were 54 patients with diffuse proliferative lupus nephritis and 6 patients with focal proliferative lupus nephritis selected from 143 patients with lupus...
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In recent years, lupus nephritis has become the major complication and the most pressing problem in patients suffering from lupus erythematosus disseminatus. The clinical course of the disease was different 15 years ago, when Keith (1940) wrote that "renal insufficiency does not play an important role in causing death". At that time patients usually died of a "lupus crisis" or as a result of co...
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associated symptoms in patients with nephritis (5). Variability in these findings can be explained by the different ethnic background of the studied sample. We have studied associated symptoms in 71 patients with lupus nephritis and 142 SLE patients without renal involvement. This sample includes all lupus patients with nephritis followed in the last five years in our service, with biopsy prove...
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ژورنال
عنوان ژورنال: Seminars in Nephrology
سال: 2015
ISSN: 0270-9295
DOI: 10.1016/j.semnephrol.2015.08.002